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Which statement is accurate regarding medications that end up being secreted in bile?

  1. All medications secreted in the bile are excreted in the feces

  2. Generally, medications are not secreted in the bile

  3. Most medications secreted in bile are metabolized in the gallbladder

  4. Some medications are excreted in the feces, while others can be recirculated to the liver many times

The correct answer is: All medications secreted in the bile are excreted in the feces

Medications that end up being secreted in bile are not always excreted in the feces. In fact, some medications undergo enterohepatic circulation, where they are reabsorbed from the intestines back into the blood and then transported back to the liver. This cycle can occur multiple times before the medications are eventually excreted in urine or feces. Therefore, it is inaccurate to say that all medications secreted in the bile are excreted in the feces.