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Which dietary habit change is most likely to cause an adverse reaction to a drug?

  1. Increase fiber intake

  2. Increase intake of grapefruit juice

  3. Reduce intake of alcohol

  4. Reduce intake of citrus fruits

The correct answer is: Increase intake of grapefruit juice

Grapefruit juice contains compounds that can interfere with the enzymes in your stomach that break down certain drugs, such as statins and calcium channel blockers. This interference can cause a higher concentration of the drug to enter your bloodstream, potentially leading to adverse reactions. Increasing fiber intake, reducing alcohol intake, and reducing citrus fruit intake do not have this same effect on drug metabolism.